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CS-W001157 4
Total: USD 88.00

2-Amino-4-chloro-5-methoxybenzoic acid

  • CAS No. 181434-76-4

  • Cat. No. CS-0146015
  • Molecule weight201.61
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Amino-4-chloro-5-methoxybenzoic acid|CS-0146015

Structure of 181434-76-4

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General Information

  • CAS No. 181434-76-4
  • Cat. No. CS-0146015
  • Purity ≥98%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClNO₃
  • Molecular Weight 201.61
  • Synonym(s) 2-AMino-4-chloro-5-Methoxy-benzoic acid
  • SMILES O=C(O)C1=CC(OC)=C(Cl)C=C1N

Description

2-Amino-4-chloro-5-methoxybenzoic acid features a strategically positioned amino group and electron-withdrawing chlorine, enabling selective coupling reactions. The methoxy substituent enhances solubility and modulates electronic properties. This scaffold serves as a key building block in the synthesis of bioactive molecules, particularly in medicinal chemistry applications requiring balanced polarity and reactivity.

Application

2-Amino-4-chloro-5-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted benzimidazoles and other heterocyclic scaffolds. Its well-defined functional group set—amino, chloro, methoxy, and carboxylic acid—supports diverse transformations including amide coupling, electrophilic substitution, and Suzuki-Miyaura cross-coupling. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for both exploratory and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   1.629
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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