Lot numbers can be found on the outside label of a product:
tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate
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CAS No. 181269-70-5
- Cat. No. CS-0048211
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 181269-70-5
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General Information
- CAS No. 181269-70-5
- Cat. No. CS-0048211
- Purity ≥97%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₂₁NO₃
- Molecular Weight 215.29
- Synonym(s) N-Boc-3-methyl-4-hydroxypiperidine
- SMILES CC1CN(CCC1O)C(=O)OC(C)(C)C
Description
tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate features a sterically hindered piperidine core with a bench-stable tert-butyl carbamate group and a pendant hydroxyl at the 4-position. This configuration enables selective derivatization in complex molecular architectures, particularly in medicinal chemistry scaffolds requiring controlled polarity and metabolic stability.
Application
tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to substituted piperidines via standard deprotection and functionalization protocols. The hydroxyl group facilitates regioselective derivatization, while the tert-butyl carbamate provides stability and orthogonal cleavage under mild acidic conditions. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis of complex heterocyclic scaffolds.
Synthesis
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Route1
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181269-69-2 - ~99%
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In-stock
181269-70-5
References
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TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LIMITED; CARROLL, Colm; GOLDBY, Anne; TEALL, Martin Patent: WO2013/179024 A1, 2013 ; Location in patent: Page/Page column 56-57 ;
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Route2
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33557-57-2 -
In-stock
24424-99-5 - ~%
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In-stock
181269-70-5
References
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THE SCRIPPS RESEARCH INSTITUTE Patent: WO2007/82079 A2, 2007 ; Location in patent: Page/Page column 34-35 ; WO 2007/082079 A2
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Route3
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In-stock
24424-99-5
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In-stock
181269-70-5
References
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NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A. Patent: WO2013/96744 A1, 2013 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 49.77
- LogP 1.6242
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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