Lot numbers can be found on the outside label of a product:
Benzo[d]thiazole-6-sulfonyl chloride
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CAS No. 181124-40-3
- Cat. No. CS-0155714
- Purity≥97%
- MDL No.MFCD03086100
*For research and further manufacturing use only, not for direct human use.
![Benzo[d]thiazole-6-sulfonyl chloride|CS-0155714](https://file.chemscene.com/productPIC/CS-0155714.gif)
Structure of 181124-40-3
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General Information
- CAS No. 181124-40-3
- Cat. No. CS-0155714
- Purity ≥97%
- MDL No. MFCD03086100
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₄ClNO₂S₂
- Molecular Weight 233.70
- Synonym(s) 1,3-Benzothiazole-6-sulfonyl chloride
- SMILES C1=CC2=C(C=C1S(=O)(=O)Cl)SC=N2
Description
Benzo[d]thiazole-6-sulfonyl chloride delivers a reactive sulfonyl chloride handle positioned ortho to the heterocyclic core, enabling direct conjugation with nucleophiles under mild conditions. This electron-deficient scaffold integrates readily into bioactive architectures, offering enhanced metabolic stability and solubility in polar media.
Application
Benzo[d]thiazole-6-sulfonyl chloride serves as a versatile building block for constructing sulfonamide-containing heterocycles, enabling efficient incorporation into pharmaceutical scaffolds. Its reactive sulfonyl chloride group facilitates direct amidation and nucleophilic substitution under mild conditions, offering high functional group tolerance and bench stability. Widely employed in medicinal chemistry, it functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive compounds, with predictable reactivity profiles suitable for both small-scale exploration and process-scale applications.
Synthesis
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Route1
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In-stock
18101-58-1 - ~%
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In-stock
181124-40-3
References
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Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4769 - 4777
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Route2
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![Benzo[d]thiazole-6-sulfonic acid|CS-0463835](https://file.chemscene.com/productPIC/CS-0463835.gif)
145708-16-3 - ~%
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In-stock
181124-40-3
References
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Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4769 - 4777
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References
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EP1803709 A1, ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 47.03
- LogP 2.2238
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 1
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