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CS-W001157 4
Total: USD 88.00

6-Bromo-2-chloroquinoline

  • CAS No. 1810-71-5

  • Cat. No. CS-W003178
  • Purity≥97%
  • MDL No.MFCD04115272

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-chloroquinoline|CS-W003178

Structure of 1810-71-5

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General Information

  • CAS No. 1810-71-5
  • Cat. No. CS-W003178
  • Purity ≥97%
  • MDL No. MFCD04115272
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅BrClN
  • Molecular Weight 242.50
  • Synonym(s) None
  • SMILES Brc1ccc2c(c1)ccc(n2)Cl

Description

DL-Isoserine has been used in the synthesis of L-isoserine derivatives s as aminopeptidase N inhibitors, Syntheses of (2R,3S)-3-Hydroxyleucinate.

Application

6-Bromo-2-chloroquinoline serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromine and chlorine substituents offer orthogonal functionalization potential, facilitating sequential derivatization. Its stability under standard reaction conditions and ease of purification make it well-suited for the construction of complex quinoline-based scaffolds in API development.

Synthesis

  • Route1

    References

    • SMITHKLINE BEECHAM CORPORATION Patent: WO2006/132739 A2, 2006 ; Location in patent: Page/Page column 36 ;
  • Route2
    • null|null
      106-40-1
    • ~%
    • In-stock
      6-Bromo-2-chloroquinoline|CS-W003178
      1810-71-5

    References

    • European Journal of Medicinal Chemistry, , vol. 35, # 10 p. 931 - 940
  • Route3
    • null|null
      6563-11-7
    • ~29%
    • In-stock
      6-Bromo-2-chloroquinoline|CS-W003178
      1810-71-5

    References

    • PROGENICS PHARMACEUTICALS, INC. Patent: WO2009/155527 A2, 2009 ; Location in patent: Page/Page column 132 ; WO 2009/155527 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.6507
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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