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CS-W001157 4
Total: USD 88.00

4,6-Dimethylpicolinic acid

  • CAS No. 18088-10-3

  • Cat. No. CS-0204920
  • Purity≥98%
  • MDL No.MFCD04113826

*For research and further manufacturing use only, not for direct human use.

4,6-Dimethylpicolinic acid|CS-0204920

Structure of 18088-10-3

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General Information

  • CAS No. 18088-10-3
  • Cat. No. CS-0204920
  • Purity ≥98%
  • MDL No. MFCD04113826
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₂
  • Molecular Weight 151.16
  • Synonym(s) 2-Pyridinecarboxylicacid,4,6-dimethyl-(9CI)
  • SMILES O=C(O)C=1N=C(C=C(C1)C)C

Description

4,6-Dimethylpicolinic acid offers a sterically hindered, electron-rich pyridine scaffold ideal for coordinating transition metals in catalytic systems. The ortho-methyl groups enhance stability and modulate reactivity, while the carboxylic acid functionality enables direct coupling or derivatization. This robust building block facilitates efficient access to functionalized heterocycles under standard conditions.

Application

4,6-Dimethylpicolinic acid serves as a versatile building block in medicinal chemistry and catalysis, offering enhanced steric and electronic properties due to its methyl-substituted pyridine core. Its carboxylic acid functionality enables direct coupling reactions, while the ortho-methyl groups provide metabolic stability and modulate solubility. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for use in API synthesis and ligand development.

Synthesis

  • Route1

    References

    • US2006/20146 A1, ; Page/Page column 40 ;
  • Route2
    • null|null
      1122-45-8
    • ~%
    • In-stock
      4,6-Dimethylpicolinic acid|CS-0204920
      18088-10-3

    References

    • Advanced Synthesis and Catalysis, , vol. 355, # 5 p. 947 - 956
  • Route3
    • null|null
      108-47-4
    • ~%
    • In-stock
      4,6-Dimethylpicolinic acid|CS-0204920
      18088-10-3

    References

    • Advanced Synthesis and Catalysis, , vol. 355, # 5 p. 947 - 956

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.39664
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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