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CS-W001157 4
Total: USD 88.00

endo-BCN-PEG3-acid

  • CAS No. 1807501-82-1

  • Cat. No. CS-0109343
  • Purity≥98%
  • MDL No.MFCD31692198

*For research and further manufacturing use only, not for direct human use.

endo-BCN-PEG3-acid|CS-0109343

Structure of 1807501-82-1

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General Information

  • CAS No. 1807501-82-1
  • Cat. No. CS-0109343
  • Purity ≥98%
  • MDL No. MFCD31692198
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₃₁NO₇
  • Molecular Weight 397.46
  • Synonym(s) None
  • SMILES O=C(OCC1C2CCC#CCCC12)NCCOCCOCCOCCC(O)=O

Description

endo-BCN-PEG3-acid features a strained cyclooctyne warhead paired with a triethylene glycol spacer and terminal carboxylic acid functionality. This design enables rapid, bioorthogonal conjugation under physiological conditions, ideal for labeling biomolecules or immobilizing probes in aqueous environments. The PEG3 linker enhances solubility and reduces nonspecific binding.

Application

endo-BCN-PEG3-acid serves as a versatile, bench-stable bifunctional linker for site-specific conjugation in bioconjugate chemistry. The norbornene moiety enables efficient inverse electron-demand Diels-Alder (IEDDA) ligation with tetrazines under physiological conditions, while the terminal carboxylic acid facilitates amide coupling or activation via standard EDC/NHS protocols. The PEG3 spacer provides solubility and reduces steric hindrance, enhancing reactivity and compatibility in protein labeling, probe synthesis, and macrocyclic scaffold construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   103.32
  • LogP   1.6767
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   14

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