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Structure of 1807025-03-1
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6-Bromo-4-(trifluoromethyl)nicotinonitrile features a trifluoromethyl group and nitrile functionality at meta positions relative to the bromine, creating a highly electron-deficient pyridine core. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring strong electron-withdrawing properties.
6-Bromo-4-(trifluoromethyl)nicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via Pd-catalyzed cross-coupling reactions. Its trifluoromethyl and nitrile groups confer enhanced metabolic stability and favorable pharmacokinetic properties, while the bromine handle facilitates efficient functionalization. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it ideal for rapid scaffold diversification in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: