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CS-W001157 4
Total: USD 88.00

2,3-Difluoro-4-nitrobenzoic acid

  • CAS No. 1806370-35-3

  • Cat. No. CS-0139378
  • Purity≥98%
  • MDL No.MFCD27922146

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-4-nitrobenzoic acid|CS-0139378

Structure of 1806370-35-3

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General Information

  • CAS No. 1806370-35-3
  • Cat. No. CS-0139378
  • Purity ≥98%
  • MDL No. MFCD27922146
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃F₂NO₄
  • Molecular Weight 203.10
  • Synonym(s) 2,3-Difluoro-4-nitro-benzoic acid
  • SMILES O=C(O)C1=CC=C([N+]([O-])=O)C(F)=C1F

Description

This difluorinated nitrobenzoic acid features a strongly electron-deficient aromatic core, enabling efficient coupling reactions in synthetic routes. The ortho-fluoro substituents enhance reactivity while maintaining stability under standard conditions.

Application

2,3-Difluoro-4-nitrobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient incorporation of fluorinated aromatic motifs. Its orthogonal functional groups—fluorine atoms at C2 and C3, a nitro group at C4, and a carboxylic acid—facilitate diverse transformations including nucleophilic aromatic substitution, amide coupling, and reduction sequences. The compound exhibits good bench stability and is readily purified by recrystallization, supporting scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   80.44
  • LogP   1.5712
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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