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CS-W001157 4
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2,3-Difluoro-5-hydroxybenzaldehyde

  • CAS No. 1806330-39-1

  • Cat. No. CS-0675259
  • Molecule weight158.10
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-5-hydroxybenzaldehyde|CS-0675259

Structure of 1806330-39-1

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General Information

  • CAS No. 1806330-39-1
  • Cat. No. CS-0675259
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₂O₂
  • Molecular Weight 158.10
  • Synonym(s) None
  • SMILES O=CC1=CC(O)=CC(F)=C1F

Description

2,3-Difluoro-5-hydroxybenzaldehyde features a trifunctional aromatic core with electron-withdrawing fluorine atoms and a reactive aldehyde group. This configuration enables selective conjugation in synthetic routes, while the hydroxyl moiety enhances solubility and provides a handle for derivatization. The molecule exhibits stability under standard bench conditions and serves as a key building block in bioactive compound development.

Application

2,3-Difluoro-5-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its ortho-difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the aldehyde and hydroxyl groups provide orthogonal handles for coupling reactions and derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in multi-step syntheses of bioactive molecules and heterocyclic intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.4829
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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