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Structure of 180624-10-6
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Methyl 4-amino-3-iodo-5-methoxybenzoate features a strategically positioned iodine atom enabling efficient late-stage functionalization. The electron-donating methoxy group enhances reactivity in cross-coupling processes, while the amino moiety offers direct handle for derivatization. This bench-stable intermediate supports rapid access to complex aromatic scaffolds under standard conditions.
Methyl 4-amino-3-iodo-5-methoxybenzoate serves as a versatile building block in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions, enabling efficient construction of biaryl and aminoaryl scaffolds. The iodine moiety facilitates reliable cross-coupling under standard conditions, while the amino and methoxy groups offer orthogonal reactivity for further functionalization. Bench-stable and amenable to purification via flash chromatography, it supports scalable synthesis of complex intermediates in medicinal chemistry and agrochemical development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: