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CS-W001157 4
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5-Bromo-3-(difluoromethyl)-2-fluoropyridine

  • CAS No. 1805222-04-1

  • Cat. No. CS-0378285
  • Molecule weight225.99
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(difluoromethyl)-2-fluoropyridine|CS-0378285

Structure of 1805222-04-1

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General Information

  • CAS No. 1805222-04-1
  • Cat. No. CS-0378285
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃N
  • Molecular Weight 225.99
  • Synonym(s) None
  • SMILES FC1=NC=C(C=C1C(F)F)Br

Description

This fluorinated pyridine scaffold integrates a bromine electrophile and a difluoromethyl group, enabling direct functionalization in cross-coupling reactions. The electron-deficient ring enhances reactivity in palladium-catalyzed transformations, while the difluoromethyl moiety imparts metabolic stability and modulates electronic properties for medicinal chemistry applications.

Application

5-Bromo-3-(difluoromethyl)-2-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromine and fluorine substituents. The difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the pyridine core provides a rigid scaffold for targeted molecular design. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.9208
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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