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CS-W001157 4
Total: USD 88.00

3-Bromo-2-chloro-6-(difluoromethyl)pyridine

  • CAS No. 1805221-46-8

  • Cat. No. CS-0370717
  • Purity≥97%
  • MDL No.MFCD25477647

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-chloro-6-(difluoromethyl)pyridine|CS-0370717

Structure of 1805221-46-8

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General Information

  • CAS No. 1805221-46-8
  • Cat. No. CS-0370717
  • Purity ≥97%
  • MDL No. MFCD25477647
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClF₂N
  • Molecular Weight 242.45
  • Synonym(s) None
  • SMILES FC(C1=CC=C(Br)C(Cl)=N1)F

Description

This difluoromethyl-substituted pyridine features a strategically positioned bromo and chloro group, enabling direct functionalization in cross-coupling reactions. The electron-deficient pyridine ring, combined with the moisture-tolerant difluoromethyl moiety, supports robust performance under standard bench conditions.

Application

3-Bromo-2-chloro-6-(difluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The difluoromethyl group imparts enhanced metabolic stability and modulates lipophilicity, while the ortho-halogenated pyridine framework supports selective functionalization. Bench-stable and compatible with standard purification protocols, it facilitates efficient synthesis of complex heterocyclic scaffolds relevant to API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.4351
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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