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Structure of 1805-65-8
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2-tert-Butyl-1H-indole features a sterically hindered tert-butyl group at the 2-position of the indole core, enhancing its stability and solubility in organic media. This substitution pattern imparts favorable handling characteristics while maintaining reactivity at the nitrogen and C3 positions for downstream functionalization.
2-tert-Butyl-1H-indole serves as a robust building block for indole-based scaffolds, offering enhanced stability and solubility due to the steric protection of the tert-butyl group. It facilitates electrophilic substitution at C3 and functions effectively in Pd-catalyzed cross-coupling reactions, enabling efficient access to substituted indoles. The molecule exhibits excellent bench stability and ease of purification, making it well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: