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CS-W001157 4
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tert-Butyl 4-vinylpiperidine-1-carboxylate,97% (stabilized with MEHQ)

  • CAS No. 180307-56-6

  • Cat. No. CS-W023013
  • Molecule weight211.30
  • Purity97% (stabilized with MEHQ)
  • MDL No.MFCD11036128

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-vinylpiperidine-1-carboxylate,97% (stabilized with MEHQ)|CS-W023013

Structure of 180307-56-6

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General Information

  • CAS No. 180307-56-6
  • Cat. No. CS-W023013
  • Purity 97% (stabilized with MEHQ)
  • MDL No. MFCD11036128
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₂
  • Molecular Weight 211.30
  • Synonym(s) 1-Boc-4-vinyl-piperidine
  • SMILES O=C(N1CCC(C=C)CC1)OC(C)(C)C

Description

tert-Butyl 4-vinylpiperidine-1-carboxylate, stabilized with MEHQ, features a reactive vinyl group enabling efficient incorporation into polymer architectures and conjugation workflows. The tert-butyl ester moiety provides stability and ease of deprotection under mild acidic conditions. This bench-stable, moisture-tolerant reagent facilitates rapid access to functionalized piperidines in synthetic and medicinal chemistry applications.

Application

tert-Butyl 4-vinylpiperidine-1-carboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized piperidine scaffolds via palladium-catalyzed cross-coupling reactions. The vinyl group facilitates reliable Heck, Suzuki-Miyaura, and Sonogashira transformations, while the tert-butyl carbamate (Boc) group provides orthogonal protection for nitrogen. This reagent exhibits excellent bench stability and ease of purification, making it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

  • Route1

    References

    • US5861414 A1, ;
  • Route2
    • null|null
      19493-09-5
    • In-stock
      tert-Butyl 4-formylpiperidine-1-carboxylate|CS-D0888
      137076-22-3
    • ~%
    • In-stock
      tert-Butyl 4-vinylpiperidine-1-carboxylate,97% (stabilized with MEHQ)|CS-W023013
      180307-56-6

    References

    • US2007/10513 A1, ; Page/Page column 20 ; US 20070010513 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.8195
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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