2-Fluoro-3-oxopentanoic acid methyl ester

Name: 2-Fluoro-3-oxopentanoic acid methyl ester
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CAS No. 180287-02-9
Cat. No. CS-M3568
Purity≥96%
MDL No.MFCD00792442

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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2-Fluoro-3-oxopentanoic acid methyl ester|CS-M3568

Structure of 180287-02-9

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Description

This methyl ester derivative features a fluorinated alkyl chain adjacent to a ketone and ester functional group, enabling precise manipulation in synthetic transformations. The electron-withdrawing fluorine enhances reactivity at the α-carbon, facilitating enolization and nucleophilic addition reactions under mild conditions. This bench-stable compound serves as a key building block for complex heterocycles and bioactive molecule synthesis.

Application

2-Fluoro-3-oxopentanoic acid methyl ester serves as a versatile building block in synthetic organic chemistry, enabling efficient access to fluorinated carbonyl intermediates. Its α-fluoro ketone functionality facilitates stereoselective transformations and acts as a key precursor in the construction of bioactive heterocycles and fluorinated pharmaceutical scaffolds. The methyl ester group enhances bench stability and simplifies purification, while the conjugated enone system supports diverse Michael additions and cyclization reactions under standard conditions.

General Information

CAS No. 180287-02-9
Cat. No. CS-M3568
Purity ≥96%
MDL No. MFCD00792442
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₉FO₃
Molecular Weight 148.13
Synonym(s) 2-Fluoro-3-oxovaleric acid methyl ester; Methyl 2-fluoro-3-oxopentanoate; Methyl 2-fluoro-3-oxovalerate
SMILES CCC(C(F)C(OC)=O)=O

Computational Chemistry Data

TPSA 43.37
LogP 0.4766
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1760
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Functional Group Ester

Building Blocks Skeleton Fatty chain compounds

Key Words

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2-Fluoro-3-oxopentanoic acid methyl ester

CAS No. 180287-02-9

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