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CS-W001157 4
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1-(Aminomethyl)cyclobutanol

  • CAS No. 180205-28-1

  • Cat. No. CS-W005666
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Aminomethyl)cyclobutanol|CS-W005666

Structure of 180205-28-1

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General Information

  • CAS No. 180205-28-1
  • Cat. No. CS-W005666
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) cyclobutanol, 1-(aminomethyl)-
  • SMILES OC1(CN)CCC1

Description

1-(Aminomethyl)cyclobutanol features a cyclobutanol ring bearing a primary amine-functionalized methylene group, offering a rigid, sterically constrained scaffold ideal for medicinal chemistry. This configuration enables direct incorporation into bioactive molecules where conformational restriction enhances target affinity and metabolic stability.

Application

1-(Aminomethyl)cyclobutanol serves as a versatile building block in medicinal chemistry, enabling the construction of saturated heterocyclic scaffolds through straightforward functionalization. Its pendant primary amine and hydroxyl groups offer orthogonal reactivity for selective derivatization, while the cyclobutane ring provides conformational rigidity beneficial for target engagement. The compound exhibits good bench stability and facilitates purification via standard chromatographic methods, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1
    • 1-(Nitromethyl)cyclobutan-1-ol|CS-0056962
      344329-87-9
    • ~%
    • In-stock
      1-(Aminomethyl)cyclobutanol|CS-W005666
      180205-28-1

    References

    • Radmer, Matthew R.; Moser, William H.; Moseman, Joan T.; Dellaria, Joseph F. Patent: US2007/155767 A1, 2007 ; Location in patent: Page/Page column 48 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.1399
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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