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2-Bromo-3-chloro-5-(difluoromethoxy)pyridine

  • CAS No. 1799420-93-1

  • Cat. No. CS-0186574
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-chloro-5-(difluoromethoxy)pyridine|CS-0186574

Structure of 1799420-93-1

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General Information

  • CAS No. 1799420-93-1
  • Cat. No. CS-0186574
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClF₂NO
  • Molecular Weight 258.45
  • Synonym(s) 2-BroMo-3-chloro-5-difluoroMethoxy-pyridine
  • SMILES FC(F)OC1=CN=C(Br)C(Cl)=C1

Description

2-Bromo-3-chloro-5-(difluoromethoxy)pyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The difluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the bromo and chloro substituents enable sequential Pd-catalyzed transformations. This scaffold integrates efficiently into complex heterocyclic architectures under mild conditions.

Application

2-Bromo-3-chloro-5-(difluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the ortho-bromine facilitates selective functionalization. Bench-stable and compatible with standard purification methods, it functions reliably in late-stage diversification of heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.0989
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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