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CS-W001157 4
Total: USD 88.00

6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one Erlotinib Impurity

  • CAS No. 179688-29-0

  • Cat. No. CS-0167035
  • Purity≥98%
  • MDL No.MFCD02678087

*For research and further manufacturing use only, not for direct human use.

6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one Erlotinib Impurity|CS-0167035

Structure of 179688-29-0

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General Information

  • CAS No. 179688-29-0
  • Cat. No. CS-0167035
  • Purity ≥98%
  • MDL No. MFCD02678087
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈N₂O₅
  • Molecular Weight 294.30
  • Synonym(s) Erlotinib'S Intermediate
  • SMILES O=C1NC=NC2=C1C=C(OCCOC)C(OCCOC)=C2

Synthesis

  • Route1
    • Ethyl 4,5-bis-(2-methoxyethoxy)-2-aminobenzoate|CS-0100395
      179688-27-8
    • null|null
      149-73-5
    • ~91%
    • 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one Erlotinib Impurity|CS-0167035
      179688-29-0

    References

    • Ube Industries, Ltd. Patent: EP1650196 A1, 2006 ; Location in patent: Page/Page column 7 ;
  • Route2
    • 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile|CS-0150175
      236750-65-5
    • null|null
      64-18-6
    • ~81%
    • 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one Erlotinib Impurity|CS-0167035
      179688-29-0

    References

    • Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
  • Route3
    • Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate|CS-0100394
      179688-26-7
    • ~%
    • 6,7-Bis(2-methoxyethoxy)quinazolin-4(3H)-one Erlotinib Impurity|CS-0167035
      179688-29-0

    References

    • Molecules, , vol. 11, # 4 p. 286 - 297

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   82.67
  • LogP   0.9735
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   8

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