N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

Name: N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine
Brand: ChemScene
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CAS No. 179552-75-1
Cat. No. CS-0160391
Purity≥97%
MDL No.MFCD30342451

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine|CS-0160391

Structure of 179552-75-1

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General Information

CAS No. 179552-75-1
Cat. No. CS-0160391
Purity ≥97%
MDL No. MFCD30342451
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₂ClFN₄O
Molecular Weight 318.73
Synonym(s) N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine
SMILES NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC

Description

N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine features a quinazoline core bearing a methoxy group at C7 and diamino substituents at C4 and C6. The para-chloro-fluoro aryl moiety enhances target affinity, while the electron-rich diamine system facilitates conjugation in kinase inhibitor scaffolds. This compound integrates readily into medicinal chemistry campaigns targeting ATP-binding domains.

Application

N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine serves as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles. Its dual amine functionality enables facile coupling reactions, while the 3-chloro-4-fluorophenyl and methoxy substituents provide enhanced solubility and metabolic stability. The compound exhibits bench-stable handling and is compatible with standard peptide and amide coupling protocols.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 73.06
LogP 3.7567
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

CAS No. 179552-75-1

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