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CS-W001157 4
Total: USD 88.00

1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane

  • CAS No. 17928-28-8

  • Cat. No. CS-0213590
  • Purity≥98%
  • MDL No.MFCD00040007

*For research and further manufacturing use only, not for direct human use.

1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane|CS-0213590

Structure of 17928-28-8

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General Information

  • CAS No. 17928-28-8
  • Cat. No. CS-0213590
  • Purity ≥98%
  • MDL No. MFCD00040007
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₃₀O₃Si₄
  • Molecular Weight 310.69
  • Synonym(s) Trisiloxane, 1,1,1,3,5,5,5-heptamethyl-3-((trimethylsilyl)oxy)-
  • SMILES C[Si](O[Si](O[Si](C)(C)C)(C)O[Si](C)(C)C)(C)C

Description

1-Boc-1,2,3,6-tetrahydropyridine is used as pharmaceutical intermediate.

Application

1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane serves as a robust silylating agent for alcohols and carboxylic acids, enabling efficient protection under mild conditions. Its bench-stable, low-viscosity form facilitates easy handling and purification, while the trimethylsilyl ether functionality offers excellent stability and orthogonal deprotection compatibility in complex synthetic sequences.

Synthesis

  • Route1
    • null|null
      1185-55-3
    • null|null
      107-46-0
    • ~88%
    • In-stock
      1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane|CS-0213590
      17928-28-8

    References

    • SHIN-ETSU CHEMICAL CO., LTD. Patent: EP1481979 A1, 2004 ; Location in patent: Page column 7-9 ;
  • Route2
    • null|null
      75-77-4
    • null|null
      75-79-6
    • ~%
    • null|null
      107-46-0
    • In-stock
      1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane|CS-0213590
      17928-28-8

    References

    • US2469888 , ; US2469890 , ; C. A., , p. 6220
  • Route3
    • null|null
      1825-62-3
    • null|null
      2031-67-6
    • ~27%
    • null|null
      107-46-0
    • In-stock
      1,1,1,3,5,5,5-Heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane|CS-0213590
      17928-28-8

    References

    • Wright, N.; Hunter, M. J. Journal of the American Chemical Society, 1947 , vol. 69, p. 803 - 809 Full Text View citing articles Show Details Gmelin Handbook: Si: MVol.C, 107, page 296 - 298

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   4.1096
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   6

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