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CS-W001157 4
Total: USD 88.00

1-Chloro-4-methoxybutane

  • CAS No. 17913-18-7

  • Cat. No. CS-0039726
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Chloro-4-methoxybutane|CS-0039726

Structure of 17913-18-7

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General Information

  • CAS No. 17913-18-7
  • Cat. No. CS-0039726
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁ClO
  • Molecular Weight 122.59
  • Synonym(s) 1-Chloro-4-methoxybuane
  • SMILES COCCCCCl

Description

1-Chloro-4-methoxybutane is a versatile alkylating agent featuring a terminal chloride and a distal methoxy group. This bifunctional structure enables selective coupling reactions in synthetic organic chemistry, particularly in the construction of ether-linked scaffolds. The molecule exhibits favorable reactivity under mild conditions and demonstrates good stability during storage and handling.

Application

1-Chloro-4-methoxybutane serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of ether-linked aliphatic chains. The terminal chloride facilitates nucleophilic substitution reactions, while the methoxy group provides stability and orthogonal reactivity. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for use in the synthesis of pharmaceutical intermediates, agrochemicals, and functionalized polymers.

Synthesis

  • Route1
    • null|null
      111-32-0
    • ~77%
    • In-stock
      1-Chloro-4-methoxybutane|CS-0039726
      17913-18-7

    References

    • ENF TECHNOLOGY CO., LTD. Patent: WO2003/104182 A1, 2003 ; Location in patent: Page 5 ;
  • Route2
    • In-stock
      4-Chlorobutan-1-ol|CS-0022417
      928-51-8
    • null|null
      74-88-4
    • ~17%
    • In-stock
      1-Chloro-4-methoxybutane|CS-0039726
      17913-18-7

    References

    • Gruenenthal GmbH Patent: US2010/48554 A1, 2010 ; Location in patent: Page/Page column 11 ;
  • Route3
    • null|null
      109-99-9
    • null|null
      67-56-1
    • ~57%
    • In-stock
      1-Chloro-4-methoxybutane|CS-0039726
      17913-18-7

    References

    • Schepens, Wim; Van Haver, Dirk; Vandewalle, Maurits; Bouillon, Roger; Verstuyf, Annemieke; De Clercq, Pierre J. Organic Letters, 2006 , vol. 8, # 19 p. 4247 - 4250

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.6518
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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