4,5,6,7-Tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-amine

Name: 4,5,6,7-Tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 17899-48-8
Cat. No. CS-0050438
Purity≥97%
MDL No.MFCD02854749

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4,5,6,7-Tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-amine|CS-0050438

Structure of 17899-48-8

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General Information

CAS No. 17899-48-8
Cat. No. CS-0050438
Purity ≥97%
MDL No. MFCD02854749
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₁N₃S
Molecular Weight 169.25
Synonym(s) thiazolo[5,4-c]pyridin-2-amine, 4,5,6,7-tetrahydro-5-methyl-
SMILES NC(S1)=NC2=C1CN(C)CC2

Description

5-Methyl-4H,5H,6H,7H-[1,3]thiazolo[4,5-c]pyridin-2-amine features a fused heterocyclic core combining thiazole and pyridine moieties, delivering enhanced electronic density and stability. This bench-stable scaffold integrates readily into kinase inhibitor scaffolds and functionalized pharmaceutical intermediates, enabling efficient access to bioactive molecules through direct coupling or cyclization reactions under standard conditions.

Application

5-Methyl-4H,5H,6H,7H-[1,3]thiazolo[4,5-c]pyridin-2-amine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its fused thiazolo-pyridine core exhibits enhanced stability and favorable electronic properties, enabling direct functionalization at the amine and methyl positions. The compound functions effectively in Pd-catalyzed cross-coupling reactions and serves as a key scaffold in the synthesis of kinase inhibitors and other bioactive molecules.

Synthesis

Route1
- 1445-73-4
- In-stock
  
  420-04-2
- ~61%
- In-stock
  
  17899-48-8
References
- GILEAD CONNECTICUT, INC.; GENENTECH, INC.; BARBOSA, Antonio, J., M.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KRISHNAMOORTHY, Ravi; KROPF, Jeffrey, E.; LEE, Seung H.; MITCHELL, Scott A.; ORTWINE, Daniel; SCHMITT, Aaron, C.; WANG, Xiaojing; XU, Jianjun; YOUNG, Wendy; ZHANG, Honglu; ZHAO, Zhongdong; ZHICHKIN, Pavel E. Patent: WO2011/140488 A1, 2011 ; Location in patent: Page/Page column 197; 198 ; WO 2011/140488 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 42.15
LogP 0.7132
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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4,5,6,7-Tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-amine

CAS No. 17899-48-8

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