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5-Fluoro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

  • CAS No. 1788062-13-4

  • Cat. No. CS-0368613
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|CS-0368613

Structure of 1788062-13-4

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General Information

  • CAS No. 1788062-13-4
  • Cat. No. CS-0368613
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇BFNO₂
  • Molecular Weight 237.08
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=CC(C)=NC=C2F)O1

Description

5-Fluoro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine features a boronate ester group enabling efficient Suzuki-Miyaura coupling under mild conditions. The electron-deficient pyridine core enhances reactivity, while the tetramethyl-substituted dioxaborolane ensures stability and ease of handling. This compound integrates readily into complex molecular architectures with high functional group tolerance.

Application

5-Fluoro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine serves as a versatile boronate building block for palladium-catalyzed cross-coupling reactions. The pyridine core enables access to biologically relevant heterocycles, while the tetramethylboronate group offers excellent stability, mild reaction conditions, and broad functional group tolerance. This reagent facilitates efficient C–C bond formation in medicinal chemistry and materials synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.82832
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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