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CS-W001157 4
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2-Bromo-5-(difluoromethyl)pyrazine

  • CAS No. 1785427-24-8

  • Cat. No. CS-0372990
  • Molecule weight208.99
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-(difluoromethyl)pyrazine|CS-0372990

Structure of 1785427-24-8

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General Information

  • CAS No. 1785427-24-8
  • Cat. No. CS-0372990
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrF₂N₂
  • Molecular Weight 208.99
  • Synonym(s) None
  • SMILES FC(C1=CN=C(Br)C=N1)F

Description

2-Bromo-5-(difluoromethyl)pyrazine features a difluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the bromine substituent enables facile cross-coupling reactions. This combination facilitates efficient integration into complex heterocyclic architectures under standard conditions.

Application

2-Bromo-5-(difluoromethyl)pyrazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to install aryl and heteroaryl groups at the 2-position. The difluoromethyl substituent enhances metabolic stability and modulates electronic properties, while the bromine facilitates reliable functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.1767
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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