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2-Bromo-8-chloro-[1,2,4]triazolo[1,5-a]pyridine

  • CAS No. 1784176-25-5

  • Cat. No. CS-0590453
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-8-chloro-[1,2,4]triazolo[1,5-a]pyridine|CS-0590453

Structure of 1784176-25-5

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General Information

  • CAS No. 1784176-25-5
  • Cat. No. CS-0590453
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClN₃
  • Molecular Weight 232.47
  • Synonym(s) None
  • SMILES ClC1=CC=CN2C1=NC(Br)=N2

Description

2-Bromo-8-chloro-[1,2,4]triazolo[1,5-a]pyridine features a fused triazolopyridine core with bromo and chloro substituents at electron-deficient positions, enabling direct functionalization in cross-coupling reactions. This bench-stable heterocycle integrates readily into bioactive scaffolds and serves as a key intermediate for pharmaceutical and agrochemical development.

Application

2-Bromo-8-chloro-[1,2,4]triazolo[1,5-a]pyridine serves as a versatile heterocyclic building block for the synthesis of pharmaceutical intermediates and functionalized triazolopyridine scaffolds. Its orthogonal halogenation pattern enables selective cross-coupling reactions, including Pd-catalyzed Suzuki and Stille couplings, facilitating rapid diversification in medicinal chemistry campaigns. The compound exhibits good bench stability and is readily purified by flash chromatography, supporting efficient integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.1452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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