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CS-W001157 4
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4-(Azetidin-3-yl)morpholine dihydrochloride

  • CAS No. 178312-50-0

  • Cat. No. CS-0046196
  • Purity≥97%
  • MDL No.MFCD11617823

*For research and further manufacturing use only, not for direct human use.

4-(Azetidin-3-yl)morpholine dihydrochloride|CS-0046196

Structure of 178312-50-0

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General Information

  • CAS No. 178312-50-0
  • Cat. No. CS-0046196
  • Purity ≥97%
  • MDL No. MFCD11617823
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆Cl₂N₂O
  • Molecular Weight 215.12
  • Synonym(s) Morpholine, 4-(3-azetidinyl)-, dihydrochloride
  • SMILES [H]Cl.[H]Cl.N1(C2CNC2)CCOCC1

Description

4-(Azetidin-3-yl)morpholine dihydrochloride features a morpholine ring fused to an azetidine moiety, delivering enhanced solubility and metabolic stability. This bifunctional scaffold integrates a tertiary amine with a strained four-membered heterocycle, enabling efficient coupling in medicinal chemistry. The dihydrochloride salt form ensures excellent crystallinity and handling convenience under standard bench conditions.

Application

4-(Azetidin-3-yl)morpholine dihydrochloride serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to constrained heterocyclic scaffolds. The azetidine moiety provides enhanced metabolic stability and improved membrane permeability, while the morpholine ring offers favorable solubility and hydrogen-bonding capacity. This compound facilitates rapid diversification in lead optimization campaigns due to its bench-stable, crystalline form and compatibility with standard coupling and functionalization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   24.5
  • LogP   0.134
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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