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Structure of 178311-48-3
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tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate features a strained azetidine core fused to a piperazine ring, delivering enhanced metabolic stability and improved solubility in polar solvents. This scaffold integrates readily into bioactive molecules, serving as a key building block for kinase inhibitors and CNS-targeted therapeutics.
tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the efficient construction of azetidine-containing scaffolds. The piperazinyl group provides enhanced solubility and hydrogen-bonding capacity, while the tert-butyl ester offers bench stability and convenient deprotection under mild acidic conditions. It functions effectively in standard coupling reactions and facilitates the incorporation of rigid, bioactive azetidine motifs into drug candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: