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CS-W001157 4
Total: USD 88.00

7-Bromochromane-3-carboxylic acid

  • CAS No. 1781758-38-0

  • Cat. No. CS-0094507
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromochromane-3-carboxylic acid|CS-0094507

Structure of 1781758-38-0

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General Information

  • CAS No. 1781758-38-0
  • Cat. No. CS-0094507
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrO₃
  • Molecular Weight 257.08
  • Synonym(s) None
  • SMILES O=C(C1COC2=CC(Br)=CC=C2C1)O

Description

7-Bromochromane-3-carboxylic acid features a brominated chromane scaffold with a carboxylic acid group at the 3-position, enabling direct conjugation or derivatization. The electron-withdrawing bromine at the 7-position modulates electronic properties and enhances reactivity in cross-coupling processes. This sterically defined, bench-stable building block supports efficient access to functionalized heterocycles for medicinal chemistry and materials applications.

Application

7-Bromochromane-3-carboxylic acid serves as a versatile building block for the synthesis of brominated chromane derivatives, enabling direct functionalization at the 7-position. Its carboxylic acid group facilitates coupling reactions and derivatization, while the chromane core provides structural rigidity and metabolic stability. The molecule exhibits good bench stability and is compatible with standard peptide coupling and transition-metal-catalyzed transformations, making it suitable for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.0848
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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