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CS-W001157 4
Total: USD 88.00

2-Aminooxazol-4(5H)-one

  • CAS No. 17816-85-2

  • Cat. No. CS-0005538
  • Purity≥97%
  • MDL No.MFCD00807941

*For research and further manufacturing use only, not for direct human use.

2-Aminooxazol-4(5H)-one|CS-0005538

Structure of 17816-85-2

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General Information

  • CAS No. 17816-85-2
  • Cat. No. CS-0005538
  • Purity ≥97%
  • MDL No. MFCD00807941
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₄N₂O₂
  • Molecular Weight 100.08
  • Synonym(s) 2-IMino-4-oxazolidione
  • SMILES O=C1N=C(N)OC1

Description

2-Aminooxazol-4(5H)-one is a bench-stable heterocyclic scaffold featuring a fused oxazolone ring with a primary amine at the 2-position. This nitrogen-rich motif integrates readily into medicinal chemistry libraries, offering enhanced solubility and hydrogen-bonding capacity for target engagement. The compound serves as a key building block in bioactive molecule synthesis.

Application

2-Aminooxazol-4(5H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of oxazolone-containing scaffolds through straightforward functionalization. Its amine and carbonyl groups provide orthogonal reactivity for coupling reactions and derivatization, while its bench-stable nature facilitates handling and purification. Functions effectively in standard peptide coupling and nucleophilic substitution protocols, supporting rapid access to diverse analogs for structure-activity studies.

Synthesis

  • Route1
    • In-stock
      Ethyl hydroxyacetate|CS-W019892
      623-50-7
    • null|null
      113-00-8
    • ~%
    • In-stock
      2-Aminooxazol-4(5H)-one|CS-0005538
      17816-85-2

    References

    • Chemische Berichte, , vol. 46, p. 2083

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.68
  • LogP   -1.1421
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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