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CS-W001157 4
Total: USD 88.00

7-Bromo-3-hydroxy-2-naphthoic acid

  • CAS No. 1779-11-9

  • Cat. No. CS-W008329
  • Purity≥98%
  • MDL No.MFCD00137823

*For research and further manufacturing use only, not for direct human use.

7-Bromo-3-hydroxy-2-naphthoic acid|CS-W008329

Structure of 1779-11-9

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General Information

  • CAS No. 1779-11-9
  • Cat. No. CS-W008329
  • Purity ≥98%
  • MDL No. MFCD00137823
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇BrO₃
  • Molecular Weight 267.08
  • Synonym(s) 7-bromo-3-hydroxynaphthalene-2-carboxylic acid
  • SMILES O=C(O)C1=C(O)C=C2C=CC(Br)=CC2=C1

Description

7-Bromo-3-hydroxy-2-naphthoic acid features a bromine substituent at the 7-position and a hydroxyl group at the 3-position, both strategically positioned on a naphthalene core. This electron-deficient scaffold integrates readily into cross-coupling workflows and offers enhanced solubility in polar media. The carboxylic acid functionality enables direct derivatization for bioconjugation or polymer synthesis.

Application

7-Bromo-3-hydroxy-2-naphthoic acid serves as a versatile building block for naphthoic acid derivatives, enabling efficient functionalization in medicinal chemistry and materials synthesis. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid and phenolic hydroxyl functionalities offer orthogonal handles for derivatization. Its bench-stable solid form and compatibility with standard protection/deprotection protocols support reliable use in multi-step syntheses.

Synthesis

  • Route1
    • 4,7-Dibromo-3-hydroxy-2-naphthoic acid|CS-W009824
      1779-10-8
    • ~95%
    • In-stock
      7-Bromo-3-hydroxy-2-naphthoic acid|CS-W008329
      1779-11-9

    References

    • Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A.; LI, Song; ZHONG, Wu; LIU, Ping; XIAO, Junhai; ZHENG, Zhibing; XIE, Yunde; ZHAO, Guoming; WANG, Xiaokui; WANG, Lili; LI, Xingzhou; ZHOU, Xinbo Patent: EP2573067 A1, 2013 ; Location in patent: Paragraph 0053; 0054 ;
  • Route2
    • null|null
      92-70-6
    • ~%
    • In-stock
      7-Bromo-3-hydroxy-2-naphthoic acid|CS-W008329
      1779-11-9

    References

    • Bioorganic and medicinal chemistry letters, , vol. 12, # 15 p. 1941 - 1946
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 132, # 49 p. 17352 - 17353

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   3.0061
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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