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CS-W001157 4
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8-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride

  • CAS No. 17783-50-5

  • Cat. No. CS-W022566
  • Molecule weight199.12
  • Purity≥97%
  • MDL No.MFCD05664035

*For research and further manufacturing use only, not for direct human use.

8-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride|CS-W022566

Structure of 17783-50-5

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General Information

  • CAS No. 17783-50-5
  • Cat. No. CS-W022566
  • Purity ≥97%
  • MDL No. MFCD05664035
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆Cl₂N₂
  • Molecular Weight 199.12
  • Synonym(s) Nsc149518
  • SMILES CN1C2CNCC1CC2.[H]Cl.[H]Cl

Description

8-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride is a sterically hindered, bench-stable nitrogen heterocycle featuring two basic amine centers. This dihydrochloride salt enhances solubility in polar media while maintaining robust reactivity, enabling efficient deprotonation and nucleophilic transformation in synthetic workflows. The methyl substitution at the 8-position modulates electronic properties and steric accessibility, offering tailored performance in catalytic systems and organic synthesis.

Application

8-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride serves as a robust, bench-stable nitrogen base enabling efficient deprotonation and catalytic activation in synthetic transformations. Its constrained bicyclic structure imparts high basicity with minimal nucleophilicity, making it ideal for selective reactions involving acid-sensitive substrates. The dihydrochloride salt enhances solubility and handling, facilitating use in amide coupling, alkylation, and heterocycle formation. Functions reliably in standard organic synthesis workflows requiring controlled basicity and excellent functional group tolerance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.896
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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