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CS-W001157 4
Total: USD 88.00

1,4-Dioxaspiro[4.5]decane

  • CAS No. 177-10-6

  • Cat. No. CS-0155307
  • Purity≥98%
  • MDL No.MFCD00005409

*For research and further manufacturing use only, not for direct human use.

1,4-Dioxaspiro[4.5]decane|CS-0155307

Structure of 177-10-6

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General Information

  • CAS No. 177-10-6
  • Cat. No. CS-0155307
  • Purity ≥98%
  • MDL No. MFCD00005409
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄O₂
  • Molecular Weight 142.20
  • Synonym(s) None
  • SMILES C1CCC2(CC1)OCCO2

Description

1,4-Dioxaspiro[4.5]decane features a rigid spirocyclic framework with two oxygen atoms positioned at the 1- and 4-positions, delivering exceptional thermal stability and controlled solubility in polar aprotic solvents. This scaffold serves as a robust molecular anchor for medicinal chemistry campaigns requiring constrained conformational space and enhanced metabolic resistance.

Application

1,4-Dioxaspiro[4.5]decane serves as a robust, bench-stable spirocyclic scaffold enabling efficient construction of complex heterocyclic systems. Its rigid, oxygen-bridged structure provides excellent functional group tolerance and facilitates regioselective transformations in medicinal chemistry applications. The compound functions as a versatile building block for synthesizing bioactive molecules, particularly in the development of constrained analogs where conformational control enhances target affinity.

Synthesis

  • Route1

    References

    • Smith, Brendan M.; Kubczyk, Tomasz M.; Graham, Andrew E. Tetrahedron, 2012 , vol. 68, # 38 p. 7775 - 7781
  • Route2
    • In-stock
      2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctane|CS-0128798
      7381-30-8
    • null|null
      108-94-1
    • ~98%
    • In-stock
      1,4-Dioxaspiro[4.5]decane|CS-0155307
      177-10-6

    References

    • Noyori, R.; Murata, S.; Suzuki, M. Tetrahedron, 1981 , vol. 37, # 23 p. 3899 - 3910
  • Route3
    • null|null
      108-94-1
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • ~99%
    • In-stock
      1,4-Dioxaspiro[4.5]decane|CS-0155307
      177-10-6

    References

    • Ballini, Roberto; Bosica, Giovanna; Frullanti, Bettina; Maggi, Raimondo; Sartori, Giovanni; Schroer, Frank Tetrahedron Letters, 1998 , vol. 39, # 12 p. 1615 - 1618

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   1.6936
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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