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(S)-(4-Chlorophenyl)(pyridin-2-yl)methanol

  • CAS No. 176022-47-2

  • Cat. No. CS-0155859
  • Molecule weight219.67
  • Purity≥98%
  • MDL No.MFCD14636162

*For research and further manufacturing use only, not for direct human use.

(S)-(4-Chlorophenyl)(pyridin-2-yl)methanol|CS-0155859

Structure of 176022-47-2

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General Information

  • CAS No. 176022-47-2
  • Cat. No. CS-0155859
  • Purity ≥98%
  • MDL No. MFCD14636162
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀ClNO
  • Molecular Weight 219.67
  • Synonym(s) (S)-alpha-(4-chlorophenyl)pyridine-2-methanol
  • SMILES C1=CC=NC(=C1)[C@H](C2=CC=C(C=C2)Cl)O

Description

(S)-4-Chlorophenyl(pyridin-2-yl)methanol is a chiral benzyl alcohol featuring a pyridine ring and a para-chlorophenyl group, enabling its use in asymmetric synthesis. The stereogenic center supports enantioselective transformations, while the electron-deficient pyridine and chlorinated aryl moieties enhance reactivity in cross-coupling and functionalization reactions. This compound offers stable handling and compatibility with standard synthetic protocols.

Application

(S)-(4-Chlorophenyl)(pyridin-2-yl)methanol serves as a valuable chiral building block in medicinal chemistry, enabling the construction of pharmacologically relevant heterocyclic scaffolds. Its well-defined stereochemistry and compatibility with standard coupling reactions facilitate efficient access to bioactive molecules. The molecule exhibits good bench stability, ease of purification, and functional group tolerance, making it suitable for iterative synthesis workflows and scale-up applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.8167
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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