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CS-W001157 4
Total: USD 88.00

2-(2,5-Dimethoxyphenyl)acetic acid

  • CAS No. 1758-25-4

  • Cat. No. CS-W010598
  • Purity≥97%
  • MDL No.MFCD00004322

*For research and further manufacturing use only, not for direct human use.

2-(2,5-Dimethoxyphenyl)acetic acid|CS-W010598

Structure of 1758-25-4

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General Information

  • CAS No. 1758-25-4
  • Cat. No. CS-W010598
  • Purity ≥97%
  • MDL No. MFCD00004322
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₄
  • Molecular Weight 196.20
  • Synonym(s) Benzeneacetic acid, 2,5-dimethoxy-
  • SMILES COC1=CC(CC(O)=O)=C(OC)C=C1

Description

2-(2,5-Dimethoxyphenyl)acetic acid features a phenyl ring bearing two methoxy groups in the 2 and 5 positions, delivering enhanced solubility and stability. This electron-rich aromatic scaffold integrates readily into bioactive molecule design, serving as a key building block for pharmaceutical intermediates and functional materials.

Application

2-(2,5-Dimethoxyphenyl)acetic acid serves as a versatile building block for the synthesis of bioactive aromatic compounds, leveraging its ortho-dimethoxy substitution pattern to facilitate electrophilic functionalization and coupling reactions. The carboxylic acid group enables direct derivatization into amides, esters, or acyl chlorides, while the benzylic position supports further modification. Its bench-stable crystalline form and predictable reactivity make it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Kennedy, Michael; McKervey, M. Anthony; Maguire, Anita R.; Naughton, Sean Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 4 p. 1041 - 1045
  • Route2
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      6202-39-7
    • ~%
    • In-stock
      2-(2,5-Dimethoxyphenyl)acetic acid|CS-W010598
      1758-25-4

    References

    • Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 15, p. 243,244
  • Route3
    • 1,4-Dimethoxybenzene, 99%|CS-1269050
      150-78-7
    • ~%
    • In-stock
      2-(2,5-Dimethoxyphenyl)acetic acid|CS-W010598
      1758-25-4

    References

    • Nippon Kagaku Zasshi, , vol. 79, p. 1110,1112, 1113 Chem.Abstr., , p. 5557

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319-H335
Precautionary Statements : P261-P264-P271-P280-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.3309
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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