Lot numbers can be found on the outside label of a product:
4,6-Dichloropyrido[3,2-d]pyrimidine
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CAS No. 175358-02-8
- Cat. No. CS-0051096
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
![4,6-Dichloropyrido[3,2-d]pyrimidine|CS-0051096](https://file.chemscene.com/productPIC/CS-0051096.gif)
Structure of 175358-02-8
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General Information
- CAS No. 175358-02-8
- Cat. No. CS-0051096
- Purity ≥97%
- MDL No. None
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₃Cl₂N₃
- Molecular Weight 200.02
- Synonym(s) 6-Dichloropyrido[3
- SMILES ClC1=NC2=C(C=C1)N=CN=C2Cl
Description
4,6-Dichloropyrido[3,2-d]pyrimidine serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring two chlorine substituents that enable selective functionalization at C4 and C6 positions. This electron-deficient core integrates readily into kinase inhibitors and antiviral agents, offering enhanced binding affinity through halogen bonding interactions. The compound exhibits bench-stable handling characteristics and compatibility with standard cross-coupling protocols under inert conditions.
Application
4,6-Dichloropyrido[3,2-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine-based scaffolds. The dichloro substitution pattern facilitates selective Suzuki-Miyaura and Buchwald-Hartwig couplings, offering reliable access to functionalized heterocycles. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis workflows in drug discovery and API development.
Synthesis
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Route1
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In-stock
![6-Chloro-3H,4H-pyrido[3,2-d]pyrimidin-4-one|CS-0050229](https://file.chemscene.com/productPIC/CS-0050229.gif)
171178-33-9 - ~91%
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In-stock
175358-02-8
References
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WO2005/58913 A1, ; Page/Page column 36 ;
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Route2
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![4-Chloropyrido[3,2-d]pyrimidin-6(5H)-one|CS-0937424](https://file.chemscene.com/productPIC/CS-0937424.gif)
1242446-83-8 - ~37%
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In-stock
175358-02-8
References
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WO2010/101949 A1, ; Page/Page column 110; 111 ; WO 2010/101949 A1
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Route3
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In-stock
93683-65-9 - ~%
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In-stock
175358-02-8
References
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Journal of Medicinal Chemistry, , vol. 39, # 9 p. 1823 - 1835
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.67
- LogP 2.3316
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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