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CS-W001157 4
Total: USD 88.00

3-Amino-4-(trifluoromethyl)pyridine

  • CAS No. 175204-80-5

  • Cat. No. CS-0005664
  • Molecule weight162.11
  • Purity≥96%
  • MDL No.MFCD00173960

*For research and further manufacturing use only, not for direct human use.

3-Amino-4-(trifluoromethyl)pyridine|CS-0005664

Structure of 175204-80-5

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General Information

  • CAS No. 175204-80-5
  • Cat. No. CS-0005664
  • Purity ≥96%
  • MDL No. MFCD00173960
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₃N₂
  • Molecular Weight 162.11
  • Synonym(s) 4-(Trifluoromethyl)pyridin-3-amine
  • SMILES FC(C1=C(N)C=NC=C1)(F)F

Description

3-Amino-4-(trifluoromethyl)pyridine features a strategically positioned trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the amino functionality enables direct coupling in C–N bond formation. This scaffold integrates readily into pharmaceutical intermediates and functional materials under standard conditions.

Application

3-Amino-4-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. The amino group facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions, while the electron-withdrawing trifluoromethyl moiety enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with common protecting group strategies streamline synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6826
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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