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Structure of 175203-87-9
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6-(Trifluoromethoxy)quinolin-4-ol integrates a trifluoromethoxy group at the 6-position and a hydroxyl moiety at the 4-position of the quinoline scaffold. This configuration imparts enhanced electron-withdrawing character and improved solubility in polar solvents, enabling efficient incorporation into bioactive scaffolds for medicinal chemistry campaigns.
6-(Trifluoromethoxy)quinolin-4-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the phenolic hydroxyl facilitates derivatization or metal-catalyzed cross-coupling. Bench-stable and compatible with common purification methods, it functions effectively in the synthesis of quinoline-based pharmaceuticals and functional materials.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: