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CS-W001157 4
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5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid

  • CAS No. 175203-84-6

  • Cat. No. CS-0080625
  • Purity≥95%
  • MDL No.MFCD00276997
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid|CS-0080625

Structure of 175203-84-6

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Description

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid integrates a trifluoromethoxy group at the 5-position of the indole core, enhancing electron-withdrawal and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis or derivatization. This bench-stable scaffold supports rapid access to bioactive heterocycles for medicinal chemistry campaigns.

Application

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds with enhanced metabolic stability and lipophilicity. Its carboxylic acid functionality facilitates direct coupling reactions, while the trifluoromethoxy group provides strong electron-withdrawing character and improved bioavailability. The compound exhibits excellent bench stability and is compatible with standard amide coupling protocols, purification by recrystallization, and functional group tolerance in multi-step syntheses.

General Information

  • CAS No. 175203-84-6
  • Cat. No. CS-0080625
  • Purity ≥95%
  • MDL No. MFCD00276997
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆F₃NO₃
  • Molecular Weight 245.15
  • Synonym(s) 5-(TRIFLUOROMETHOXY)INDOLE-2-CARBOXYLIC ACID
  • SMILES FC(F)(F)OC1=CC(C=C(C(O)=O)N2)=C2C=C1

Computational Chemistry Data

  • TPSA   62.32
  • LogP   2.7647
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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