Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid

  • CAS No. 175203-84-6

  • Cat. No. CS-0080625
  • Molecule weight245.15
  • Purity≥95%
  • MDL No.MFCD00276997

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid|CS-0080625

Structure of 175203-84-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 175203-84-6
  • Cat. No. CS-0080625
  • Purity ≥95%
  • MDL No. MFCD00276997
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆F₃NO₃
  • Molecular Weight 245.15
  • Synonym(s) 5-(TRIFLUOROMETHOXY)INDOLE-2-CARBOXYLIC ACID
  • SMILES FC(F)(F)OC1=CC(C=C(C(O)=O)N2)=C2C=C1

Description

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid integrates a trifluoromethoxy group at the 5-position of the indole core, enhancing electron-withdrawal and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis or derivatization. This bench-stable scaffold supports rapid access to bioactive heterocycles for medicinal chemistry campaigns.

Application

5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds with enhanced metabolic stability and lipophilicity. Its carboxylic acid functionality facilitates direct coupling reactions, while the trifluoromethoxy group provides strong electron-withdrawing character and improved bioavailability. The compound exhibits excellent bench stability and is compatible with standard amide coupling protocols, purification by recrystallization, and functional group tolerance in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   62.32
  • LogP   2.7647
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 175203-84-6 sigma175203-84-6 manufacturer175203-84-6 price175203-84-6 structure175203-84-6 SDSbuy 175203-84-6175203-84-6 supplier175203-84-6 uses175203-84-6 molecular weightprice of 175203-84-6175203-84-6 chemical name formula of 175203-84-6
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label