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Structure of 175203-84-6
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5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid integrates a trifluoromethoxy group at the 5-position of the indole core, enhancing electron-withdrawal and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis or derivatization. This bench-stable scaffold supports rapid access to bioactive heterocycles for medicinal chemistry campaigns.
5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds with enhanced metabolic stability and lipophilicity. Its carboxylic acid functionality facilitates direct coupling reactions, while the trifluoromethoxy group provides strong electron-withdrawing character and improved bioavailability. The compound exhibits excellent bench stability and is compatible with standard amide coupling protocols, purification by recrystallization, and functional group tolerance in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: