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CS-W001157 4
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rel-(1S,2S)-2-(2-Fluorophenyl)cyclopropane-1-carboxylic acid

  • CAS No. 175168-71-5

  • Cat. No. CS-0047730
  • Purity≥95%
  • MDL No.MFCD24386958

*For research and further manufacturing use only, not for direct human use.

rel-(1S,2S)-2-(2-Fluorophenyl)cyclopropane-1-carboxylic acid|CS-0047730

Structure of 175168-71-5

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General Information

  • CAS No. 175168-71-5
  • Cat. No. CS-0047730
  • Purity ≥95%
  • MDL No. MFCD24386958
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉FO₂
  • Molecular Weight 180.18
  • Synonym(s) (1S,2S)-2-(2-fluorophenyl)cyclopropane-1-carboxylic Acid
  • SMILES O=C([C@@H]1[C@@H](C2=CC=CC=C2F)C1)O

Description

rel-(1S,2S)-2-(2-Fluorophenyl)cyclopropane-1-carboxylic acid is a stereochemically defined cyclopropane carboxylic acid featuring a fluorinated aromatic substituent. This configuration imparts enhanced metabolic stability and targeted binding affinity in bioactive molecule design. The compound serves as a key chiral building block for medicinal chemistry applications, particularly in the development of CNS-targeted therapeutics.

Application

rel-(1S,2S)-2-(2-Fluorophenyl)cyclopropane-1-carboxylic acid serves as a stereochemically defined building block for bioactive cyclopropane-containing scaffolds. Its functional group tolerance enables direct incorporation into medicinal chemistry campaigns, while the rigid, chiral cyclopropane core facilitates conformational control in target molecules. The compound exhibits bench stability and is compatible with standard synthetic transformations, including derivatization to amides, esters, and acyl chlorides, supporting efficient route development for API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.0138
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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