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CS-W001157 4
Total: USD 88.00

5-Cyclopropyl-1H-pyrazol-3-amine

  • CAS No. 175137-46-9

  • Cat. No. CS-W009073
  • Purity≥97%
  • MDL No.MFCD00082760

*For research and further manufacturing use only, not for direct human use.

5-Cyclopropyl-1H-pyrazol-3-amine|CS-W009073

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General Information

  • CAS No. 175137-46-9
  • Cat. No. CS-W009073
  • Purity ≥97%
  • MDL No. MFCD00082760
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) BUTTPARK 47\04-27
  • SMILES NC1=NNC(C2CC2)=C1

Description

5-Cyclopropyl-1H-pyrazol-3-amine features a pyrazole core with a cyclopropyl group at the 5-position and a primary amine at the 3-position, enabling direct functionalization in medicinal chemistry. This scaffold delivers enhanced metabolic stability and favorable solubility profiles, facilitating integration into bioactive molecules for drug discovery applications.

Application

5-Cyclopropyl-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazole-based heterocycles through standard coupling and functionalization reactions. The cyclopropyl group enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates derivatization via acylation, alkylation, or cross-coupling protocols. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for scalable synthesis and API development.

Synthesis

  • Route1

    References

    • Pharmacia and Upjohn S.p.A; Pharmacia and Upjohn Co. Patent: US6218418 B1, 2001 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.8693
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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