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CS-W001157 4
Total: USD 88.00

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline

  • CAS No. 1745-07-9

  • Cat. No. CS-W005976
  • Purity≥95%
  • MDL No.MFCD00777849

*For research and further manufacturing use only, not for direct human use.

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline|CS-W005976

Structure of 1745-07-9

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General Information

  • CAS No. 1745-07-9
  • Cat. No. CS-W005976
  • Purity ≥95%
  • MDL No. MFCD00777849
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES COC1=CC2=C(C=C1OC)CCNC2

Description

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline is a bench-stable, electron-rich heterocycle featuring two methoxy groups at the 6 and 7 positions. This configuration enhances solubility and stability while providing a versatile scaffold for medicinal chemistry applications. The tetrahydroisoquinoline core integrates readily into bioactive molecules, enabling efficient access to targeted pharmacophores.

Application

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive alkaloid derivatives. Its dimethoxy substitution pattern enhances solubility and metabolic stability while maintaining compatibility with standard coupling and functionalization reactions. The tetrahydroisoquinoline core functions as a privileged scaffold in CNS-targeted drug discovery, offering predictable stereochemical control and robust bench stability under routine handling conditions.

Synthesis

  • Route1
    • null|null
      110098-01-6
    • ~18%
    • null|null
      3526-89-4
    • In-stock
      6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline|CS-W005976
      1745-07-9
    • null|null
      120-20-7

    References

    • Journal of the American Chemical Society, , vol. 109, # 19 p. 5859 - 5861
  • Route2

    References

    • Hajipour; Mohammadpoor-Baltork; Noroallhi Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 2 p. 152 - 156
  • Route3
    • null|null
      50-00-0
    • null|null
      120-20-7
    • ~92%
    • In-stock
      6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline|CS-W005976
      1745-07-9

    References

    • Louafi, Fadila; Hurvois, Jean-Pierre; Chibani, Aissa; Roisnel, Thierry Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5721 - 5724

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.49
  • LogP   1.3495
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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