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CS-W001157 4
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7-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

  • CAS No. 1745-05-7

  • Cat. No. CS-0043245
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride|CS-0043245

Structure of 1745-05-7

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General Information

  • CAS No. 1745-05-7
  • Cat. No. CS-0043245
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄ClNO
  • Molecular Weight 199.68
  • Synonym(s) 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
  • SMILES COC1=CC2=C(C=C1)CCNC2.Cl

Description

7-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a methoxy group at the C7 position. This electron-rich scaffold integrates readily into medicinal chemistry campaigns, offering enhanced solubility and metabolic stability. The hydrochloride salt form ensures excellent crystallinity and handling ease in synthetic workflows.

Application

7-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a stable, bench-ready building block for the synthesis of bioactive alkaloids and pharmaceutical intermediates. Its well-defined nitrogen functionality enables straightforward functionalization in standard coupling and alkylation reactions, while the methoxy group provides predictable regioselectivity in electrophilic substitutions. The hydrochloride salt enhances solubility and handling convenience in aqueous or polar organic media, facilitating purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • WO2004/69256 A1, ; Page/Page column 50 ; WO 2004/069256 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.7627
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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