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CS-W001157 4
Total: USD 88.00

4-Aminobenzo[b]thiophene

  • CAS No. 17402-83-4

  • Cat. No. CS-0139684
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Aminobenzo[b]thiophene|CS-0139684

Structure of 17402-83-4

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General Information

  • CAS No. 17402-83-4
  • Cat. No. CS-0139684
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NS
  • Molecular Weight 149.21
  • Synonym(s) BENZO[B]THIOPHEN-4-YLAMINE
  • SMILES NC1=C(C=CS2)C2=CC=C1

Description

4-Aminobenzo[b]thiophene features a fused thiophene and benzene ring system with a strategically positioned amino group, delivering enhanced electron density for use in conjugated materials. This bench-stable heterocycle integrates readily into pharmaceutical scaffolds and organic semiconductors, offering predictable reactivity under standard conditions.

Application

4-Aminobenzo[b]thiophene serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of biologically active compounds through standard coupling reactions. Its amino group provides a handle for derivatization, while the benzo[b]thiophene core offers enhanced metabolic stability and favorable π-stacking interactions. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows targeting kinase inhibitors and other pharmacologically relevant scaffolds.

Synthesis

  • Route1
    • null|null
      62100-46-3
    • ~92%
    • In-stock
      4-Aminobenzo[b]thiophene|CS-0139684
      17402-83-4

    References

    • Bonini, Carlo; Funicello, Maria; Scialpi, Rosanna; Spagnolo, Piero Tetrahedron, 2003 , vol. 59, # 38 p. 7515 - 7520
  • Route2
    • 4-Nitrobenzo[b]Thiophene|CS-0768028
      10133-34-3
    • ~%
    • In-stock
      4-Aminobenzo[b]thiophene|CS-0139684
      17402-83-4

    References

    • Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
  • Route3
    • null|null
      18044-91-2
    • ~%
    • In-stock
      4-Aminobenzo[b]thiophene|CS-0139684
      17402-83-4

    References

    • Journal of the American Chemical Society, , vol. 77, p. 5939,5943

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H301+H311+H331-H315-H319
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4835
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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