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CS-W001157 4
Total: USD 88.00

2-Methoxyacetonitrile

  • CAS No. 1738-36-9

  • Cat. No. CS-0128800
  • Purity≥97%
  • MDL No.MFCD00001892

*For research and further manufacturing use only, not for direct human use.

2-Methoxyacetonitrile|CS-0128800

Structure of 1738-36-9

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General Information

  • CAS No. 1738-36-9
  • Cat. No. CS-0128800
  • Purity ≥97%
  • MDL No. MFCD00001892
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅NO
  • Molecular Weight 71.08
  • Synonym(s) Methoxyacetonitrile
  • SMILES N#CCOC

Application

2-Methoxyacetonitrile serves as a versatile synthetic building block, enabling efficient access to β-methoxy nitriles and related heterocycles. Its reactivity facilitates nucleophilic addition, cyanohydrin formation, and transition-metal-catalyzed coupling processes. The molecule exhibits bench stability, ease of handling, and compatibility with common protecting group strategies, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      123-38-6
    • null|null
      88057-24-3
    • ~0%
    • In-stock
      2-Methoxyacetonitrile|CS-0128800
      1738-36-9
    • null|null
      158068-81-6

    References

    • Clive, Derrick L. J.; Etkin, Nola Tetrahedron Letters, 1994 , vol. 35, # 16 p. 2459 - 2462
  • Route2
    • null|null
      109-87-5
    • null|null
      7677-24-9
    • ~62%
    • In-stock
      2-Methoxyacetonitrile|CS-0128800
      1738-36-9

    References

    • Utimoto, Kiitiro; Wakabayashi, Yukio; Horiie,Takafumi; Inoue, Masaharu; Shishiyama, Yuho; et al. Tetrahedron, 1983 , vol. 39, # 6 p. 967 - 974
  • Route3
    • null|null
      544-92-3
    • null|null
      107-30-2
    • ~80%
    • In-stock
      2-Methoxyacetonitrile|CS-0128800
      1738-36-9

    References

    • Bakker, C. G.; Scheeren, J. W.; Nivard, R. J. F. Recueil: Journal of the Royal Netherlands Chemical Society, 1981 , vol. 100, # 1 p. 13 - 20

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H302+H312+H332
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.02
  • LogP   0.15638
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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