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CS-W001157 4
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tert-Butyl (10-hydroxydecyl)carbamate

  • CAS No. 173606-54-7

  • Cat. No. CS-0120628
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (10-hydroxydecyl)carbamate|CS-0120628

Structure of 173606-54-7

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General Information

  • CAS No. 173606-54-7
  • Cat. No. CS-0120628
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₃₁NO₃
  • Molecular Weight 273.41
  • Synonym(s) 10-(t-Boc-amino)-1-decanol
  • SMILES O=C(NCCCCCCCCCCO)OC(C)(C)C

Description

tert-Butyl (10-hydroxydecyl)carbamate features a hydroxylated aliphatic chain appended to a stable tert-butyl carbamate protecting group. This combination enables selective conjugation and orthogonal deprotection in complex synthesis workflows. The molecule exhibits enhanced solubility in organic solvents and maintains stability under standard bench conditions, facilitating efficient incorporation into peptide and macrocyclic architectures.

Application

tert-Butyl (10-hydroxydecyl)carbamate serves as a stable, bench-friendly protecting group for primary amines, enabling selective amidation and coupling reactions in complex molecule synthesis. The pendant hydroxyl group allows for orthogonal functionalization via esterification or ether formation, supporting modular construction of polyfunctional scaffolds. Its compatibility with standard deprotection protocols and ease of purification make it well-suited for iterative synthetic workflows in medicinal chemistry and natural product synthesis.

Synthesis

  • Route1
    • null|null
      173606-53-6
    • ~74%
    • In-stock
      tert-Butyl (10-hydroxydecyl)carbamate|CS-0120628
      173606-54-7

    References

    • Huang; Wei, Huang; Kalivretenos; Kalivretenos, Aristotle G. Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9113 - 9116
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    References

    • Nakanishi, Shuichi; Tanaka, Hiroyuki; Hioki, Kazuhito; Yamada, Kohei; Kunishima, Munetaka Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7050 - 7053
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    References

    • Huang; Wei, Huang; Kalivretenos; Kalivretenos, Aristotle G. Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9113 - 9116

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   3.6242
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   10

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