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CS-W001157 4
Total: USD 88.00

5-Bromo-1,3-dichloro-2-fluorobenzene

  • CAS No. 17318-08-0

  • Cat. No. CS-W003716
  • Purity≥98%
  • MDL No.MFCD09996901

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1,3-dichloro-2-fluorobenzene|CS-W003716

Structure of 17318-08-0

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General Information

  • CAS No. 17318-08-0
  • Cat. No. CS-W003716
  • Purity ≥98%
  • MDL No. MFCD09996901
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂BrCl₂F
  • Molecular Weight 243.89
  • Synonym(s) Benzene, 5-bromo-1,3-dichloro-2-fluoro-
  • SMILES Brc1cc(Cl)c(c(c1)Cl)F

Description

5-Bromo-1,3-dichloro-2-fluorobenzene features a highly functionalized aromatic core with halogen substituents enabling direct coupling in cross-coupling reactions. The strategic placement of bromo, chloro, and fluoro groups facilitates selective transformations, while the electron-deficient ring enhances reactivity in palladium-catalyzed processes. This compound serves as a robust scaffold for synthesizing complex fluorinated aromatics used in pharmaceuticals and agrochemicals.

Application

5-Bromo-1,3-dichloro-2-fluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity profile. The strategic placement of bromo, chloro, and fluoro substituents provides orthogonal functionalization potential and enhanced metabolic stability. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient route development for complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.895
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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