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CS-W001157 4
Total: USD 88.00

Ethyl 2-amino-2-methylpropanoate hydrochloride

  • CAS No. 17288-15-2

  • Cat. No. CS-0127822
  • Purity≥97%
  • MDL No.MFCD06809830

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-amino-2-methylpropanoate hydrochloride|CS-0127822

Structure of 17288-15-2

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General Information

  • CAS No. 17288-15-2
  • Cat. No. CS-0127822
  • Purity ≥97%
  • MDL No. MFCD06809830
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO₂
  • Molecular Weight 167.63
  • Synonym(s) Iflab-Bb F2108-0015
  • SMILES NC(C)(C(OCC)=O)C.Cl

Description

Ethyl 2-amino-2-methylpropanoate hydrochloride features a sterically hindered α-amino ester core with enhanced solubility in polar solvents. This bench-stable derivative enables direct incorporation into peptide couplings and amine-functionalized intermediates without requiring protection. The protonated amine facilitates salt formation, improving handling and storage stability in synthetic workflows.

Application

Ethyl 2-amino-2-methylpropanoate hydrochloride serves as a versatile building block in peptide and heterocyclic synthesis, offering a readily accessible tertiary amine with orthogonal reactivity. Its stability under standard conditions facilitates straightforward handling and purification, while the protected amine group enables efficient coupling reactions and incorporation into β-amino acid scaffolds. Functions effectively in Mannich-type cyclizations and as a precursor to bioactive amine-containing motifs.

Synthesis

  • Route1
    • α-Aminoisobutyric acid|CS-0229297
      62-57-7
    • ~67%
    • In-stock
      Ethyl 2-amino-2-methylpropanoate hydrochloride|CS-0127822
      17288-15-2

    References

    • Roche Palo Alto LLC Patent: US2007/42988 A1, 2007 ; Location in patent: Page/Page column 18; 22 ;
  • Route2
    • null|null
      64-17-5
    • α-Aminoisobutyric acid|CS-0229297
      62-57-7
    • ~99%
    • In-stock
      Ethyl 2-amino-2-methylpropanoate hydrochloride|CS-0127822
      17288-15-2

    References

    • Cianci, Julia; Baell, Jonathan B.; Harvey, Andrew J. Tetrahedron Letters, 2007 , vol. 48, # 34 p. 5973 - 5975
  • Route3
    • null|null
      64-17-5
    • In-stock
      Methyl 2-aminoisobutyrate hydrochloride|CS-W002520
      15028-41-8
    • ~92%
    • In-stock
      Ethyl 2-amino-2-methylpropanoate hydrochloride|CS-0127822
      17288-15-2

    References

    • Leibfritz, Dieter; Haupt, Erhard; Dubischar, Norbert; Lachmann, Heinrich; Oekonomopulos, Raymond; Jung, Guenther Tetrahedron, 1982 , vol. 38, # 14 p. 2165 - 2182

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.7086
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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