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CS-W001157 4
Total: USD 88.00

Spiro[2.5]octane-1-carboxylic acid

  • CAS No. 17202-86-7

  • Cat. No. CS-0055830
  • Molecule weight154.21
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Spiro[2.5]octane-1-carboxylic acid|CS-0055830

Structure of 17202-86-7

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General Information

  • CAS No. 17202-86-7
  • Cat. No. CS-0055830
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄O₂
  • Molecular Weight 154.21
  • Synonym(s) None
  • SMILES C1CCC2(CC1)CC2C(=O)O

Description

Spiro[2.5]octane-1-carboxylic acid features a rigid, three-dimensional spirocyclic core that imparts exceptional conformational stability and spatial control. This scaffold integrates a carboxylic acid group at the bridgehead position, enabling direct coupling in peptide synthesis or conjugation strategies without epimerization risk. The molecule's steric shielding enhances metabolic resistance and improves membrane permeability in bioactive compound design.

Application

Spiro[2.5]octane-1-carboxylic acid serves as a rigid, three-dimensional building block for medicinal chemistry and materials science applications. Its spirocyclic core imparts conformational stability and enhances metabolic resistance, while the carboxylic acid group enables facile derivatization via amide, ester, or salt formation. The compound exhibits good bench stability and is compatible with standard coupling protocols, facilitating integration into complex molecular architectures.

Synthesis

  • Route1
    • null|null
      17202-88-9
    • ~%
    • In-stock
      Spiro[2.5]octane-1-carboxylic acid|CS-0055830
      17202-86-7

    References

    • Seyden-Penne,J.; Roux-Schmitt,M.-C. Bulletin de la Societe Chimique de France, 1968 , p. 3810 - 3812
  • Route2
    • null|null
      20778-46-5
    • ~%
    • In-stock
      Spiro[2.5]octane-1-carboxylic acid|CS-0055830
      17202-86-7

    References

    • Seyden-Penne,J.; Roux-Schmitt,M.-C. Bulletin de la Societe Chimique de France, 1968 , p. 3810 - 3812
  • Route3
    • null|null
      22308-11-8
    • ~%
    • In-stock
      Spiro[2.5]octane-1-carboxylic acid|CS-0055830
      17202-86-7

    References

    • Seyden-Penne,J.; Roux-Schmitt,M.-C. Bulletin de la Societe Chimique de France, 1968 , p. 3810 - 3812

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.0414
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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