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CS-W001157 4
Total: USD 88.00

2-Methyl-4-phenylbut-3-yn-2-ol

  • CAS No. 1719-19-3

  • Cat. No. CS-0154963
  • Purity≥97%
  • MDL No.MFCD00041572

*For research and further manufacturing use only, not for direct human use.

2-Methyl-4-phenylbut-3-yn-2-ol|CS-0154963

Structure of 1719-19-3

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General Information

  • CAS No. 1719-19-3
  • Cat. No. CS-0154963
  • Purity ≥97%
  • MDL No. MFCD00041572
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O
  • Molecular Weight 160.21
  • Synonym(s) TIMTEC-BB SBB008964
  • SMILES CC(C)(C#CC1=CC=CC=C1)O

Description

2-Methyl-4-phenylbut-3-yn-2-ol features a conjugated alkyne linkage flanked by a tertiary alcohol and a phenyl group, enabling direct incorporation into Sonogashira coupling reactions. This bench-stable scaffold delivers high functional group tolerance and facilitates rapid access to complex aryl-substituted alkynes in synthetic workflows.

Application

2-Methyl-4-phenylbut-3-yn-2-ol serves as a versatile alkynyl building block in synthetic organic chemistry, enabling efficient access to conjugated enynes and functionalized heterocycles. Its terminal alkyne functionality facilitates reliable copper-catalyzed coupling reactions, while the tertiary alcohol offers stability and ease of purification. The molecule functions effectively in Sonogashira, Glaser, and Huisgen cycloadditions, supporting streamlined synthesis of complex scaffolds for medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      108-86-1
    • null|null
      115-19-5
    • ~98%
    • In-stock
      2-Methyl-4-phenylbut-3-yn-2-ol|CS-0154963
      1719-19-3

    References

    • Zou, Haixia; Zhou, Liyan; Li, Yuanzhen; Cui, Yi; Zhong, Hanbing; Pan, Zhengying; Yang, Zhen; Quan, Junmin Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 994 - 1003
  • Route2
    • null|null
      536-74-3
    • null|null
      67-64-1
    • ~98%
    • In-stock
      2-Methyl-4-phenylbut-3-yn-2-ol|CS-0154963
      1719-19-3

    References

    • Imahori, Tatsushi; Hori, Chieko; Kondo, Yoshinori Advanced Synthesis and Catalysis, 2004 , vol. 346, # 9-10 p. 1090 - 1092
  • Route3
    • In-stock
      Iodobenzene|CS-W008603
      591-50-4
    • null|null
      115-19-5
    • ~92%
    • In-stock
      2-Methyl-4-phenylbut-3-yn-2-ol|CS-0154963
      1719-19-3

    References

    • Lin, Bo-Nan; Huang, Shao-Hsien; Wu, Wei-Yi; Mou, Chung-Yuan; Tsai, Fu-Yu Molecules, 2010 , vol. 15, # 12 p. 9157 - 9173

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.809
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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